PT-141 (Bremelanotide): A Research Peptide Overview
PT-141 (Bremelanotide) is a melanocortin receptor agonist studied in preclinical sexual-function research. A neutral overview for laboratory use only.
PT-141, also known as Bremelanotide, is a synthetic peptide widely referenced in laboratory literature on the melanocortin system. This overview summarizes what PT-141 is, how it is described mechanistically, and how researchers handle it. All content is provided for laboratory research use only; not for human consumption.
PT-141 is a cyclic heptapeptide derived from the earlier compound Melanotan II, and it is studied as a reference agonist at melanocortin receptors.
What is PT-141?
PT-141 (Bremelanotide) is a small synthetic peptide investigated in the context of melanocortin signalling. Unlike its precursor, it lacks the pigmentation-focused profile and is characterized in the literature primarily as a melanocortin receptor agonist. In research settings it is used as a well-defined reference molecule when studying this receptor family.
Mechanism of action
In preclinical and in-vitro research, PT-141 is described as an agonist at melanocortin receptors, with reported activity at the MC3 and MC4 receptor subtypes. These receptors are studied for their role in central nervous system signalling pathways. Investigators use PT-141 to probe receptor binding, downstream signalling, and comparative pharmacology.
Receptor selectivity
Published studies characterize the relative affinity of PT-141 across melanocortin receptor subtypes. Such data help researchers interpret assay results and design controlled comparisons with other melanocortin ligands.
Research context
PT-141 appears in preclinical literature exploring sexual-function pathways and central melanocortin signalling. Findings are reported strictly at the level of laboratory and animal models. Nothing here should be read as clinical guidance; observations are attributed to specific studies and remain hypotheses under investigation. When sourcing material for such work, verified third-party lab results support reproducibility.
Handling and storage
Lyophilized PT-141 is typically stored cold and protected from light and moisture. For reconstitution planning in the laboratory, a peptide reconstitution calculator helps document target concentrations. Good practice includes:
- Storage: keep lyophilized powder frozen; minimize freeze–thaw cycles once in solution.
- Reconstitution: use appropriate sterile diluents and record concentrations.
- Documentation: label aliquots and retain certificate-of-analysis data.
Key takeaways
- PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist peptide.
- It is characterized in research at MC3/MC4 receptor subtypes.
- It appears in preclinical sexual-function and signalling literature.
- Proper cold storage and documented reconstitution support reproducible work.
- It is a laboratory reference material, not a therapeutic product.
Research use disclaimer
PT-141 supplied by Purevito is intended for in-vitro laboratory research only. It is not for human or veterinary use, is not a medicine, and must not be administered to humans or animals. It is not intended to diagnose, treat, cure, or prevent any condition. Explore our research peptides catalogue for full specifications.
About this topic
Compiled by
Scientific basis
Based on peer-reviewed scientific literature and research data.
Last reviewed
21 August 2026
